Friday, August 29, 2014
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What's the connection between gut health and the immune system?

Learn more about how our gut health contributes to our body's immune system, and it begins even before we're born.

What's the connection between gut health and the immune system?

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Our bodies have natural barriers that protect us from infection. The skin, what we think of as a physical barrier, is a significant immunological barrier as well. That means that there are immune molecules in the skin that help fight off bacteria and other infectious agents.

From our time in the womb throughout childhood development, our bodies are learning how to tolerate certain substances and fight off others. Our immune system starts off with a genetic component and exposure to foods, bacteria and other agents helps shape it.  As we grow, defense mechanisms in our gut and respiratory tract keep us healthy and free from infections. In an ideal situation, the body recognizes an infection that poses a threat and fights it off, while at the same time recognizes and allows bacteria in that are helpful to digestion. There is this ongoing monitoring – known as immune surveillance – that enables us to get rid of what is harmful and keep what is helpful.

Other barriers include the mucosal lining of the eyes, nose, mouth, respiratory tract and gastrointestinal tract. This is important because while protecting us from dangerous foreign substances in the environment, these barriers also have to let certain things in.  After all, we have to breathe, take in nutrients, and drink diet sodas without our bodies trying to expel what is foreign to them.

The gut is a very important barrier.  There are products on the market, such as yogurts, and supplements, that promise improved gut health by adding healthy bacteria to one’s diet. Commercial bias aside, the immune system is so complex that no one factor is guaranteed to be of benefit in every individual. Vitamin D, along with nutrition, a healthy lifestyle and one’s genetic makeup, all contribute to gut health.

A preponderance of evidence shows that breastfeeding benefits the immune system and may prevent the development of allergies. There is ongoing research about the benefits of exclusive breastfeeding for a particular period of time and some controversy regarding what the optimal length of exclusive breast feeding time should be, when to introduce solid foods, and which foods to introduce at what time. 

On the whole, however, breastfeeding is good for babies in many ways, including immune system balance. Remember, everyone has a unique genetic predisposition which can be modulated by the environment. What is good for one child may not have the same benefit for another.  


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Christopher C. Chang, M.D., Ph.D Nemours/Alfred I. duPont Hospital for Children, Jefferson Medical Colg
About this blog
The Healthy Kids blog is your window into the latest news, research and advice around children's health. Learn more about our growing list of contributors here.

If you have questions about your child's health, ask them here.

Anna Nguyen Healthy Kids blog Editor
Stephen Aronoff, M.D., M.B.A. Temple University Hospital
Peter Bidey, D.O. Medical Director of Family Medicine at Philadelphia College of Osteopathic Medicine
Christopher C. Chang, M.D., Ph.D Nemours/Alfred I. duPont Hospital for Children, Jefferson Medical Colg
Mario Cruz, M.D. St. Christopher’s Hospital for Children, Drexel University College of Medicine
Katherine K. Dahlsgaard, Ph.D. Lead Psychologist - The Anxiety Behaviors Clinic, CHOP
Gary A. Emmett, M.D. Director of Hospital Pediatrics at TJU Hospital & Pediatrics Professor at Thomas Jefferson Univ.
Lauren Falini Bariatric exercise physiologist, Nemours/Alfred I. duPont Hospital for Children
Hazel Guinto-Ocampo, M.D. Nemours duPont Pediatrics/Bryn Mawr Hospital
Rima Himelstein, M.D. Crozer-Keystone Health System
Jessica Kendorski, PhD, NCSP, BCBA-D Associate Professor in School Psychology/Applied Behavior Analysis at Philadelphia College of Osteopathic Medicine
Anita Kulick President & CEO, Educating Communities for Parenting
Janet Rosenzweig, MS, PhD, MPA VP for Programs & Research for Prevent Child Abuse America
Beth Wallace Smith, R.D. Children's Hospital of Philadelphia
W. Douglas Tynan, Ph.D. Nemours/Alfred I. duPont Hospital for Children, Jefferson Medical Colg
Flaura Koplin Winston, M.D., Ph.D Scientific Director of the Children’s Hospital of Philadelphia’s Center for Injury Research and Prevention
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