The former Oregon star, part of a winning relay in 2015, posted the third-fastest time in carnival history in the mile.
After losing a narrow victory in the opening relay, the United States came back to run a record time of 1:35.20, one of the host nation's five victories in the six-event competition.
The Wildcats' women wrapped up a three-win carnival for the second straight year while the 'Nova men captured two relays, their first multiple titles at Penn since 1984.
Athletes from Pennsylvania and South Jersey had good days on a sunny afternoon.
The winner of Olympic gold, silver and bronze medals in the 100 meters is the reigning World Champion at 36 years old.
Neumann-Goretti girls set new school record in the 4×800 at the Penn Relays
"He said, `Scotty, at your age and the shape you're in, you have to do track and field,'" Scott recalled. "I told him I hadn't done anything like that since 10th grade, but he showed me a few things, and I've been doing it ever since."
It's USA vs. the World day at Franklin Field, and there are also big high school and college Championship of America races
The former Olympian has been competing at the carnival since 2001 when he ran for Tennessee, and says returning every year is "like a dream."
The former NFL wide receiver won the 100 meters in the 55-and-older Master race at the Penn Relays.
Welcome to our live coverage of Friday's action at the 2018 Penn Relays. Keep this page bookmarked all day for race results, photos and all the fun anecdotes from Franklin Field that make the event special.
It was the Wildcats' sixth women's DMR championship in the last seven years, and the program's 16th overall.
The Delsea senior finished second in the girls' pole vault during Thursday's Penn Relays events.