Games are Sunday unless noted.
If Andrew Luck throws for 424 yards, he'll become the second fastest to reach 20,000 in a career (72 games). He'll also give panic attacks to fans already on edge after the spell FitzMagic put on the secondary last week. By the way, Matthew Stafford (71 games) has the record. Colts rookie linebacker Darius Leonard had 18 tackles last week at Washington and forced the fumble that essentially clinched the game. The Eagles have won 12 in a row at home, not counting that meaningless loss to Dallas in Week 17 last year.
Postgame headline: Refs gone wild — Colts defensive players flagged just for thinking about hitting Wentz
Plenty of drama in Pittsburgh with star wide receiver Antonio Brown taking an unauthorized personal day Monday. Boy, can't a guy take a day off? Between the lines, it's the Steelers defense that has been getting waxed. Through two games, it is 28th in points allowed, and it gave up 38 of the 45 points Jacksonville put on the Steelers in the playoff loss last year. Ryan Fitzpatrick joined Dan Marino (1984) and Billy Volek (2004) as the only quarterbacks in NFL history with 400 passing yards and four TDs in consecutive games. (Yeah, Billy Volek.) Marino had 340 yards and four TDs in that third game; Volek had 111 yards.
Postgame headline: Bucs still undefeated, Steelers still winless; What in the name of Chuck Noll is going on around here?
This game was off the board in Vegas for most of the week as Titans QB Marcus Mariota dealt with an injured right (throwing) hand. The Titans swept the Jags last year, including a 37-16 thumping in Jacksonville. Jags coach Doug Marrone had the same reaction to that wonderful one-handed catch Keelan Cole made last week against the Patriots. "I'm like everyone else. … Wow," the coach said. "But he has made those catches in training camp. He has done that before."
Postgame headline: Mariota plays, wishes he hadn't
The Saints (8-11) and the Eagles (3-6) are the only teams Matt Ryan has a losing record against among those against which he's made more than five starts. Drew Brees had just three TD passes and two picks last year in the two meetings, each won by the home team. New Orleans, fifth in rushing last season, is dead last through Week 2 as running back Mark Ingram continues his four-game suspension.
Postgame headline: Falcons roll as Julio (two TDs) tells Michael Thomas 'not in my dome'
First meeting between Los Angeles teams since the Raiders beat the Rams at Anaheim Stadium in 1994. First meeting between these franchises since 2014 when St. Louis lost at San Diego. (Is this a football capsule or a geography lesson?) Matchup of great running backs.
Postgame headline: Visiting Chargers surprised so many people go to football games in L.A.
Patrick Mahomes became the first quarterback with 10 touchdown passes through Week 2. He needs three to pass Peyton Manning (2013) for the most through Week 3. He might get that by halftime. This will be his first home game as Kansas City's starter.
Postgame headline: Teams honor 62-year-old former quarterback Joe Montana by playing to a 62-62 tie
Three of Cincinnati's top four running backs are hurt, most notably Joe Mixon. Giovani Bernard will do the heavy lifting. "I feel like people are freaking out, but my goodness, it's football," Bernard said. Love athletes who say "my goodness."
Postgame headline: Cam Newton runs for more yards than Bengals
The Seahawks have lost five of six dating to last season. Their only victory was against Dallas in Week 16. Seattle won that game despite managing just 136 yards of offense.
Postgame headline: Russell Wilson recalls the good ol' days when Seattle had a running game
Matt Patricia goes against mentor Bill Belichick in a game sponsored by the men's clothing rack at CVS. (Seriously, who dresses these guys?) The concussion Detroit cornerback Darius Slay is dealing with is much more urgent than Gronk's ankle.
Postgame headline: No Slay? No way. Patriots roll
FanDuel is offering the Broncos at 750-1, but you better be quick. Just kidding. Both teams have key divisional games in Week 4. Denver will host Kansas City, and Baltimore will be at Pittsbugh. Focus on Week 3, fellas.
Postgame headline: Ravens hold Phillip Lindsay to under 100 yards. Wait … who's Phillip Lindsay?
The Redskins went 5 for 15 on third down last week against the Colts. If the Skins do anything similar, and keep punting the ball away, Aaron Rodgers will carve them up.
Postgame headline: Bob Woodward to write book about odd disappearance of Redskins fans
This will be the first road start for Bills rookie quarterback Josh Allen. Would love to see Buffalo, 16 1/2-point underdogs, at least keep it competitive. Would also love to have tonight's winning lottery numbers. Neither is happening.
Postgame headline: Poor Buffalo plays the Packers at Lambeau next week
Jadeveon Clowney should be back in the lineup in time to face a Giants offensive line that was shredded by the Cowboys last week.
Postgame headline: Only a matter of time until frustrated Beckham tangles with a kicking net again
The Cardinals have been outscored by 58-6, so the coaches thought it would be motivational to play audio of the team being booed by the home crowd in Week 1. Isn't that a tad asinine? "We can't play any worse than we did the last two weeks," Larry Fitzgerald said. "All you can go is up."
Postgame headline: Fitzgerald deserves better in his twilight
The Dolphins are 9-1 in Ryan Tannehill's last 10 starts. The Raiders' lack of pass rush is obvious in light of the Khalil Mack trade, but Oakland also has been awful against the run, allowing 5.7 yards per carry.
Postgame headline: Winless Raiders seek asylum in south Florida