Mike Lewis II scored 11 of his 24 points in the third overtime; Tarin Smith, who finished with 21 points, forced a critical La Salle turnover late in the second overtime; and Duquesne beat the Explorers, 101-94, in triple overtime on Saturday.
After La Salle's Pookie Powell hit two free throws to make it 92-all with 2 minutes, 29 seconds remaining, Lewis scored all of Duquesne's points in a 9-2 run to close the game. The Explorers (7-11, 1-4 Atlantic Ten) missed five of their final six field-goal attempts.
Jamir Moultrie hit a three to give La Salle a 73-67 lead early in the first overtime, and two free throws by Amar Stukes pushed the lead to four points with 13 seconds left.
Powell led La Salle with 22 points.
Jordan Robinson finished with 13 points and 10 rebounds, and Eric Williams Jr. added 10 points and 13 boards for Duquesne (13-5, 4-1).
The Dukes missed 3 of 4 from the free-throw line — including the front end of a one-and-one — and La Salle made just 1 of 3 in the final 1:37 of regulation.