St. Louis-based pharmacy benefit management firm Express Scripts Holding Co. is shutting down its 53,000 square-foot office at the Bucks County Technology Park in Trevose and laying off about 220 workers at the site.

Express Scripts spokesman Brian Henry said in an interview Thursday that the office had become unnecessary because computerized systems had reduced the number of people necessary to process prescriptions.

Some 50 workers at the Trevose office are being given the opportunity to work from home or at another site, Henry said. Express Scripts employs about 2,000 people statewide, with offices in Blue Bell, North Huntingdon, and Warrendale, he said.

The Trevose facility will close May 26. The company's lease for the space expires at the end of June.

Express Scripts is the nation's largest stand-alone pharmacy benefits manager, with $100.3 billion in revenue in 2016, according to its most recent annual report.

The Bucks County Technology Park, at 4800 E. Street Rd., is currently 95 percent occupied, according to its website.