"I hate you! America made," an Eagles fan yelled to protesters outside Lincoln Financial Field.
Saquon Barkley accounted for a career-high 211 rushing yards and a program record 358 all-purpose yards.
Trace McSorley and Juwan Johnson sealed the deal with a 7-yard scoring pass on the game's final play against Iowa.
Giroux, one of the NHL's highest-scoring centers the last seven seasons, will make his debut at left wing in Monday's exhibition game at the New York Rangers.
The Eagles' changing of the left guard is official, two games into the season.
About two dozen players took a knee. Other players on both teams stood arm-in-arm with Jacksonville owner Shad Khan.
Some revealing Eagles stats through their first two games.
Robert Kraft, who has been a strong backer of Trump, expressed "deep disappointment" with him.
The fourth-ranked Nittany Lions dominated on offense all night, getting 211 rushing yards and 358 all-purpose yards from Saquon Barkley, but needed the last play of the game to defeat the Hawkeyes
The Flyers have 27 healthy players left in training camp, and they plan to carry 23 for the Oct. 4 opener in San Jose.
Carson Wentz is the Eagles' leading rusher after two games. It won't stay that way, but his running ability will be a factor this season
In his second season as Eagles coach, Doug Pederson is growing into being a more demanding leader.
Will the Eagles run more on Sunday? How will a depleted secondary affect the defense?
No matter the size, situation or time of season, Darren Sproles has always come through. So why has he never been the featured running back?