Joel Embiid finished with 17 points, nine rebounds, three assists, one steal and one block.
The Sixers beat the Magic on the glass, 56-40, leading to 32 fast break points in a rout in Orlando.
Thursday's game in Orlando was a homecoming for Sixers point guard Ben Simmons and shooting guard JJ Redick.
The Sixers starters were subbed out with 3:45 left in the third quarter and didn't have to return to the game.
Wednesday's 119-105 win over Memphis gave the Sixers a 20-7 record against teams with sub-.500 records this season.
The Sixers have their sights set on one of the top four playoff seeds in the Eastern Conference. A win over the Grizzlies was the latest step.
Memphis has a center in Marc Gasol who is capable of being a serious challenge to Joel Embiid, but on this night it never happened.
The Sixers won their 40th game of the season with an easy victory over the Grizzlies.
Brett Brown still plans on resting Embiid in one of the final 12 games of the season.
Memphis, though, has won the previous 10 meetings with the Sixers.
Under Jay Wright, Villanova has become perhaps the best college basketball program in the country. Where does that put him on the city's all-time list of great coaches?
Brett Brown says that when Joel Embiid is available for every practice and shoot-around, "watch out" because he'll be even better than he is now.
Ben Simmons became the first rookie in NBA history with 15 assists and zero turnovers while recording a triple-double since turnovers became an official stat in the 1977-78 season.