Tony Parker's 37 points lead the Spurs over the Sixers

Something about Wednesdays and point guards doesn't work out well for the 76ers.

Two weeks after Deron Williams torched the Sixers - and three after Andre Miller did the same thing - Tony Parker scored a game-high 37 points, the most any player has scored against the Sixers all season, to carry the San Antonio Spurs to a 100-90 win Wednesday night in front of 18,070 at the Wells Fargo Center.

"Tony Parker was amazing tonight," Sixers coach Doug Collins said. "He had the ball on a string, and we were trying to do our best to keep him corralled, make him shoot jump shots. And we just never, never could get him under control."

The Sixers (18-8), who played without the injured Spencer Hawes (sore left Achilles tendon), are 0-5 when they give up at least 100 points. The Spurs (18-9) were without guard Manu Ginobili, out since Jan. 2 with a broken bone in his left hand.

Parker, who scored 21 of his points in the second half, almost single-handedly kept the Sixers at bay, getting his shots off the pick-and-roll or just penetrating to the basket. When the Sixers fouled him, Parker delivered: He was 13 for 13 from the line. He also had eight assists.

"We were really just trying to get the ball out of his hands, that's about it," said Sixers point guard Jrue Holiday, who finished with 15 points and seven assists.

Before Parker helped the Spurs to their sixth win in a row, the Wells Fargo Center witnessed other impressive Wednesday-night performances from visiting point guards in January. Former Sixer Andre Miller came off the bench to score 28 points and hand out 10 assists and lift Denver past the Sixers, 108-104. Deron Williams was masterful, scoring 34 points and handing out 10 assists as the New Jersey Nets defeated the Sixers, also in overtime, 97-90.

Like Parker's performance, much of that earlier offense came off the screen-and-roll.

"That's the game right now," Holiday said. "Sometimes we have trouble, and sometimes I think we do very well. But every guard that has come in here and had a big game has been an all-star or a veteran player."

After Andre Iguodala (17 points, seven rebounds, four assists) gave the Sixers a 51-50 lead with 10 minutes, 11 seconds to play in the third quarter, the Spurs took the lead back on Tim Duncan's 16-foot jumper and never relinquished it. The lead reached 10 points later in the third, and Holiday's goal-tend of a Parker shot put it at 12 with just over nine minutes left in the fourth. Even though the Sixers were able to cut the lead to just five points, the Spurs always seemed to have an answer.

Lou Williams led the Sixers with 22 points, and Elton Brand, who had missed the Sixers' previous two games with a sprained right thumb, finished with 11 points and 13 rebounds for his fifth double-double of the season.