Luis Garcia surrendered the lead in the bottom of the eighth.
They will complete the season without using one. The shortage extends to the high minors.
He gave up five runs in the first inning, sucking the life out of the offense.
The 24-year-old Puerto Rico native achieved a dream last month when the Phillies promoted him to the majors, but it's hard to focus on anything but his homeland.
Rhys Hoskins and Nick Williams had big hits, but L.A. avoided a sweep.
Sean Doolittle has never played a Major League game in Citizens Bank Park, but starred there in the Carpenter Cup.
"Professional is how I wanted to handle it," Joseph said. "I understand right now what needs to happen."
Therrien, 24, underwent Tommy John surgery earlier this week. He had an 8.35 ERA with the Phillies.
Aaron Altherr had four RBIs in his last two plate appearances to give the Phillies their third straight win against the best team in baseball.
The rookie has yet to show his power stroke, but he has been getting on base.
He hit a bases-loaded double to the wall in left-center field to break the game open.
Scott Kingery and Tom Eshelman received the Paul Owens Award on Tuesday night and should reach the majors sometime in 2018.
TORONTO (AP) - Kansas City's Alex Gordon broke Major League Baseball's season home run record with 12 days to spare, hitting the 5,694th long ball of 2017 on Tuesday night.
The Phillies' Aaron Altherr hit the first grand slam ever given up by Dodgers ace Clayton Kershaw.