The Phillies were stymied by Cardinals rookie Jack Flaherty, who had 13 strikeouts.
Meneses was a single shy of the cycle in the IronPigs' shutout win against Syracuse.
Dominguez pitched the final two innings of Saturday's 7-6 comeback win over the Cardinals to earn his first save. The righthander has been brilliant as a reliever, starting his major-league career by retiring 20 of the 21 batters he has faced in his first six games.
Scott Kingery hit a two-out, two-strike triple in the eighth to tie the game. He then scored the winning run.
Jake Arrieta only lasted three innings, plagued by errors in a rain-delayed 12-4 loss to the Cardinals.
Ben Lively pitched six innings of one-run ball, and Joey Meneses homered for the third time in as many games to lead the IronPigs in a 2-1 win over Syracuse.
The Phillies are only a quarter of the way through their season, but there are plenty of reasons to believe they are legit.
Nick Williams played against Santa Fe High when he played four sports in high school. "It's sickening, to be honest," Williams said.
Zach Eflin was perhaps pitching a bit too nice. The Phillies wanted him to be mean and the results are showing.
The Phillies hoped Alfaro could emerge as a leader behind the plate, and his maturation there has been central to their success this season.
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The IronPigs lost in 11 innings Thursday after jumping out to a 4-2 lead against the Yankee-affiliated Scranton/Wilkes-Barre.
Seranthony Dominguez provided two key outs and the Phillies opened the four-game series with a win.