Eagles wide receiver Jeremy Maclin tore the ACL in his right knee. The injury typically requires season-ending surgery, costing the 25-year-old receiver the year.
Maclin fell to the ground during a non-contact drill in Saturday's practice. He was carted off the field.
The Eagles are now missing a starting receiver two practices into the season. Riley Cooper took the first-team snaps in Maclin's place.
The injury is especially devastating because Maclin, who was entering the final year of his contract, was expecting the best season of his career. A former first-round pick who has been a four-year starter with the Eagles, Maclin has been a consistent contributor but never exceeded 1,000 yards in a season.