Saint Joseph's has its first three-game winning streak of the season and made an important move in the Atlantic 10 standings.
The Wildcats knocked down 16 three-point baskets and got a big win that kept them in the hunt for a fifth straight conference regular-season title.
Alex Louin scored 20 points for Villanova, and Ashley Russell and Phoebe Sterba racked up 14 points each for Penn on Friday.
To beat No. 4 Xavier, the third-ranked Wildcats must cut down on turnovers, play better on the boards and pay more attention to detail, coach Jay Wright said.
La Salle, Drexel, Villanova, St. Joseph's and Penn will all be playing.
The Big East is scoring at historic rates, but defense is often what wins in March and April.
It's the 20th anniversary of O'Sullivan's 100th sub-four-minute mile.
The Wildcats made a season-low three three-point baskets in 20 attempts and committed 19 turnovers in suffering the upset loss.
Point guard Jahvon Quinerly decommitted from Arizona last October after the assistant coach who recruited him was arrested in a federal college basketball corruption case.
One of the best three-point shooting teams all season, the Wildcats are 27.5 percent on threes in their last two games and face another tough perimeter defense in Providence.
Villanova graduate Ryan Fannon has been broadcasting Villanova sports for half of his life.
Two City Six men's basketball games are on tap for Wednesday.
Villanova is shooting 40.8 percent from three-point range to lead the Big East.