Houston quickly grabbed control of a game that had big NCAA implications for Temple.
The Owls surrendered the game's first 15 points and weren't competitive against a game they needed to win.
Knight will replace the spot of cornerbacks coach Cory Robinson, who is expected to be hired at Rutgers.
Houston is coming off Thursday's home win over No. 5 Cincinnati, while Temple fell at No. 19 Wichita State.
WICHITA, Kan. (AP) - As his teammates headed to the locker room after allowing 56 first-half points, Wichita State senior center Shaquille Morris witnessed their frustration.
Temple is going for its sixth consecutive wins when the Owls visit nationally ranked Wichita State on Thursday.
Villanova is shooting 40.8 percent from three-point range to lead the Big East.
The schedule will open at Lincoln Financial Field against Villanova and close at UConn.
Statistical history shows you need a top defense to win an NCAA hoops title. The Wildcats rank 48th by one measurement.
Temple outscored the Bulls 27-11 over the final 11 minutes, 35 seconds. The Owls held USF without a field goal for more than seven minutes during that stretch.
Quinton Rose scored 23 points as the Owls took care of business against a struggling team.
The Owls had signed 25 in the early period in December and another four on Wednesday
Top-ranked Villanova hosts St. John's at the Wells Fargo Center and Temple is home with East Carolina, while La Salle travels to George Washington.