The Quakers will play Missouri-Kansas City at 5 p.m. Wednesday in a consolation game.
Justin Watson completed his Quakers career as the school's top receiver of all time.
The 59-point victory margin was the largest in Penn basketball history.
The Quakers coasted after leading 43-16 at halftime. Ryan Betley and Caleb Wood finished with 13 points each.
La Salle beat Penn in two overtimes, but both squads looked at how this one went to 50 minutes.
The Explorers' starting guard scored eight of his 12 points in the second extra period at the Palestra.
The Quakers, despite having three league losses, remain in the Ivy League title picture heading into Saturday's game at Harvard.
Penn's stretch run last season was no mirage. They lost at Harvard by 10 in February and won by three in March.
The Crimson haven't won the Ivy League since their four-year run from 2012 through 2015 but their talented young players have made them the pre-season favorite.
Penn will play Villanova at the Jake Nevin Field House and at Dayton, but they also have a nine-game homestand in the middle of their schedule.
Penn, winner of six of its last eight games last season, comes back feeling it can contend for an Ivy League tournament berth again.
Wrapping up the local football weekend, with Mike Kern's Top 10 and Fraud Five
For as turbulent as this season has been at Penn, Saturday's win will live long in the program's memory.