Elon's Meme Garner nailed a three-pointer for a nine-point lead with 2 minutes, 11 seconds left in regulation, and the Phoenix went on to take a 57-45 victory and repeat as conference champions.
Drexel will play Elon Saturday for the program's first NCAA bid since 2009
The Dragons will face Delaware in the semifinals on Friday.
The Dragons are tied for first in the Colonial Athletic Association with James Madison. Both teams have their regular season finales on Saturday.
The Dragons have played in 11 games decided by one possession this season, and are 6-5 in those contests. That includes a 1-1 mark against James Madison, their opening-round CAA tournament opponent.
Drexel lost to end the regular season, plus any chance of getting a bye in the Colonial Athletic Association Tournament.
Penn overcame a 15-point deficit, but couldn't complete the comeback against Harvard. Villanova routed Providence, and Drexel outlasted James Madison after double overtime.
Drexel returns to the court after setting an NCAA Division I record by overcoming a 34-point deficit in Thursday's 85-83 win over Delaware.
The players and coaches have heard from many well-wishers after setting an NCAA record by overcoming a 34-point deficit to beat Delaware, 85-83, on Thursday.
Delaware won the first meeting this year, 72-66, at home.
After Sunday's loss to Houston, Temple has virtually no margin for error.
La Salle, Drexel, Villanova, St. Joseph's and Penn will all be playing.
Temple is going for its sixth consecutive wins when the Owls visit nationally ranked Wichita State on Thursday.