Kurk Lee and Sammy Mojica combined for 42 points for the Dragons.
Junior guard Tramaine Isabell, a transfer from Missouri, scored a career-high 35 points , including 22 in the second half to lead the Dragons to a non-league win over the Broncos.
The Dragons trailed by 11 points early in the second half and by eight with under four minutes left.
A scoring drought in the second half was too difficult to overcome, resulting in the Dragons' extended losing streak.
Tramaine Isabell, a transfer from Missouri, led Drexel with 22 points.
Dragons leader Kurk Lee shot just 3-for-14 from the field, while Falcons guard Justin Turner poured in 33 points.
Kurk Lee, the super quick point guard from Baltimore, had some help last season, but not nearly enough.
The Dragons' guard rotation is five deep and they may use as many as four guards on the floor at once.
Kurk Lee is the leading returning scorer for Drexel after averaging 14.9 ppg. Sammy Mojica and Miles Overton are the top seniors.
After finishing 10th last season, the Dragons were picked ninth in the preseason poll. College of Charleston is the favorite, along with Towson, Hofstra and Elon.
"I have a whole family that enjoys every game that I play,'' Lee said. "This is bigger than me. It's family."
The two are competing for the Broad Street Brawlers in The Basketball Tournament.
He held off the veteran Jeff Osberg to prevail in the Golf Association of Phila. event at Overbrook Golf Club.