Duke is almost a sure bet in the first two rounds of the NCAA tournament, advancing to the round of 16 in 11 of the last 13 seasons.
It's the third game that's become a hurdle for the program, which boasts the tournament's highest all-time winning percentage.
The top-seeded Blue Devils (31-5) will try to reach the round of eight for the first time since 2004 when they face No. 4 seed Purdue (29-5) tonight in Houston.
Duke is 90-30 in the tournament all-time but has lost to lower-seeded teams in the regional semifinals in three of the last five seasons.
The Boilermakers are back in the regional semifinals for the second straight year, but they haven't made the round of eight since 2000. It's surprising that they made it this far after losing junior forward Robbie Hummel to a knee injury in late February.
St. Mary's vs. Baylor - With his dominating play and crackling one-liners, Omar Samhan is ensuring that people take notice of the surprising Gaels (28-5).
He says he'll be ready to face the Bears (27-7) tonight in Houston because he knows that if he's if he's not, people will say he was having too much fun and wasn't focused.
"When it's time to play, you better bring it," he said.
The Baylor trio at the podium, led by senior guard Tweety Carter, already appeared to be in game mode.
"We're here on a business trip," post player Ekpe Udoh said.
A preseason pick by the Big Twelve coaches to finish 10th in its own league, Baylor instead was the No. 3 seed in the South Regional.