The Mega Millions jackpot is the game's fifth biggest ever, after no one matched all the numbers drawn Tuesday night.
They were: 9, 14, 56, 57 and 69, with a Mega Ball of 10.
Two tickets came close, winning $1 million each, for matching the first five numbers, but not the Mega Ball. They were sold in Texas and Washington State.
The new jackpot, for Friday's drawing, is $353 million for the annuity, and $194 million for the cash, topped by only a half-dozen other jackpot runs.
For any U.S. lottery, the annuity is No. 12, the cash No. 15. That includes Powerball and Mega Millions' precursor, the Big Game.
See "Biggest jackpots in U.S. lottery history"
Mega Millions drastically altered its setup in October, lengthening the odds of winning by 50 percent (1 chance in 256 million for a single ticket) and reconfiguring its annuity, which boosted the most-advertised number relative to the cash. (See: "Mega Millions jackpot: Artificially sweetened?")
After the changes, a jackpot rose to No. 2 all-time, $648 million, with the fourth biggest cash prize ever, $347.6 million.
So this jackpot could be a rollover or two from rocketing to that orbit, possibly setting up a record run this month.
More more on lotteries, go to Philly.com's lottery page, or the websites for Mega Millions or Powerball.
Contact staff writer Peter Mucha at 215-854-4342 or firstname.lastname@example.org.