| Rank | Company | Founded | Ownership | Sector | Locations | Employees |
| 1 | Open Systems Healthcare | 2011 | Private | Home Healthcare Services | 5 | 755 |
| 2 | Power Home Remodeling Group | 1992 | Private | Home improvement | 2 | 580 |
| 3 | Duane Morris LLP | 1904 | Private | Law | 2 | 626 |
| 4 | SAP Americas | 1972 | Private | Enterprise Software | 1 | 2925 |
| 5 | PricewaterhouseCoopers LLP | 1874 | Partnership | Professional Services | 1 | 1900 |
| 6 | Harrah's Philadelphia Casino and Racetrack | 2006 | Parent company | Entertainment | 1 | 740 |
| 7 | Toll Brothers, Inc. | 1967 | Public | Homebuilding | 4 | 947 |
| 8 | Turnersville AutoMall | 1991 | Public | Auto Dealership | 9 | 610 |
| 9 | Philadelphia Insurance Companies | 1962 | Private | General Insurance | 1 | 622 |
| 10 | Liberty Lutheran Services | 2001 | Non-profit | Non-Profit Senior Living Organization | 7 | 611 |
| 11 | MossRehab | 1900 | Non-profit | Rehabilitation hospital | 18 | 795 |
| 12 | SPIN | 1970 | Non-profit | Human Services | 8 | 1084 |
| 13 | AmerisourceBergen Corporation | 2001 | Public | Global Pharmaceutical Services | 3 | 1066 |
| 14 | Pennoni | 1966 | Private | Engineering | 6 | 552 |
| 15 | Reed Technology & Information Services | 1966 | Public | Professional services | 1 | 669 |
| 16 | Vertex Inc. | 1978 | Private | Technology product sales and service | 3 | 675 |
| 17 | JEVS Human Services | 1941 | Non-profit | Human and social services | 35 | 881 |
| 18 | Kennedy Health | 1965 | Non-profit | Hospitals | 3 | 3571 |
| 19 | SugarHouse Casino | 2010 | Private | Casino Entertainment | 1 | 1574 |
| 20 | Comcast Corporation | 1963 | Public | Media and Technology | 90 | 10908 |
| 21 | PRA Health Sciences | 1982 | Public | CRO | 1 | 556 |
| 22 | Freedom Mortgage Corporation | 1990 | Private | Financial Services | 6 | 2129 |
| 23 | De Lage Landen Financial Services | 1969 | Private | Financial Solutions | 1 | 926 |
| 24 | Premier Orthopaedics | 2000 | Private | Orthopaedics | 45 | 534 |
| 25 | Center For Family Services, Inc. | 1920 | Non-profit | Human services | 50 | 855 |
| 26 | Rothman Institute | 1970 | Private | Physicians Practice | 26 | 987 |
| 27 | Mastery Charter Schools | 2001 | Non-profit | Non-profit | 22 | 1618 |
| 28 | Beneficial Bank | 1853 | Public | Financial Services & Insurance | 65 | 780 |
| 29 | SEI | 1968 | Public | Financial Services | 11 | 2537 |
| 30 | Burlington Stores, Inc. | 1972 | Public | Off-Price Retail | 26 | 3705 |