Barcelona at Real Madrid
9:55 a.m. Saturday (beIN Sport)
After knocking Barcelona out of the Copa del Rey on Tuesday, Madrid hosts its fierce rival in a league game this weekend. Real's Cristiano Ronaldo has finally emerged from the shadow of Barça's Lionel Messi, whose place as the world's best player came at Ronaldo's expense.
D.C. United at Houston Dynamo
8:00 p.m. Saturday (NBC Sports Network)
Last year's Eastern Conference finalists meet again. Both teams have added big-time forwards to boost their attacks: Houston traded for Colorado's Omar Cummings and and D.C. signed former Union striker Carlos Ruiz.
Chicago Fire at Los Angeles Galaxy
5:00 p.m. Sunday (Uni Más)
With David Beckham gone and Landon Donovan on sabbatical, Robbie Keane will lead L.A.'s quest for a third straight MLS Cup. Chicago bolstered its midfield in the offseason by trading for Chestnut Hill Academy grad Jeff Larentowicz.
Arsenal at Tottenham Hotspur
10:30 a.m. Sunday (Fox Soccer Channel)
Tottenham's Gareth Bale has been English soccer's biggest star this season, with 15 goals in 24 games. Arsenal needs to beat its North London rival to keep up in the race for next season's Champions League.
New York Red Bulls at Portland Timbers
7:30 p.m. Sunday (ESPN2)
The league's most telegenic fan base hosts another nationally-televised season opener. New York's Mike Petke and Portland's Caleb Porter will be making their head coaching debuts.
Real Madrid at Manchester United
2:30 p.m. Tuesday (Fox Soccer Channel)
After a 1-1 tie in Madrid, the scene shifts to Manchester. A United win would rank among famed manager Sir Alex's Ferguson's greatest achievements.
Seattle Sounders at Tigres UANL
10:00 p.m. Wednesday (Fox Soccer Channel)
The Sounders are one of three MLS teams in the CONCACAF Champions League quarterfinals, along with Houston and Los Angeles.