Games to Watch: MLS, EPL, La Liga, Serie A, Liga MX

Real Salt Lake at Seattle Sounders

10:00 p.m. Friday (NBCSN)

After helping the U.S. clinch a World Cup berth, Clint Dempsey and Eddie Johnson return home to Seattle to face Major League Soccer’s best team. The Sounders can take first place in the west away from RSL with a win.

Arsenal at Sunderland

10:00 a.m. Saturday (NBCSN)

American star Jozy Altidore has had a rough start to life at Sunderland. He hasn’t played too well under manager Paolo di Canio, and missed the Black Cats’ last game due to a hamstring injury. He’ll try to get things on track against Arsenal, led by new star Mesut Özil.

Juventus at Inter Milan

12:00 p.m. Saturday (beIN Sport)

Both teams in Serie A’s Derby D’Italia have enjoyed unbeaten starts to the season. It’s no surprise that reigning champ Juventus is playing well. Inter is the underdog, and will rely on goalkeeper Samir Handanovic to keep Bianconeri stars Carlos Tévez and Andrea Pirlo at bay.

Chelsea at Everton

12:30 p.m. Saturday (NBC)

Everton and U.S. national team goalkeeper Tim Howard shut out Mexico on Tuesday. The New Jersey native faces another big challenge this weekend, as Frank Lampard and Juan Mata lead a star-studded Chelsea attack into Goodison Park.

Los Angeles Galaxy at D.C. United

4:00 p.m. Saturday (UniMás)

In MLS’ early years, this was the league’s signature rivalry. Now, with D.C. in the doldrums, it’s simply a must-win for Landon Donovan and the Galaxy.

Real Madrid at Villareal

4:00 p.m. Saturday (beIN Sport)

Gareth Bale is expected to make his Real Madrid debut this weekend, and he has a lot of hype to live up to. Madrid paid a world record $132 million transfer fee for Welsh winger to become Cristiano Ronaldo’s teammate. We’ll start to find out this weekend whether Bale was worth the money.

Club Tijuana at Chivas Guadalajara

6:00 p.m. Sunday (UniMás)

Just a few days after the U.S.-Mexico World Cup qualifier, the cross-border rivalry takes a new twist in Mexico's domestic league.

Tijuana has four Americans on its squad, including U.S. national team regulars Joe Corona and Edgar Castillo. Chivas famously refuses to sign any players who aren’t full-blooded Mexicans. That policy is why the Goats are Mexico’s most popular team – but it might also be why they haven’t won a championship since 2006.