Asante Samuel and Riley Cooper are both out of Sunday's game against the 49ers with concussions, taking away the team's best cornerback and leaving them without their fourth wide receiver.
Head coach Andy Reid said he expects running back LeSean McCoy to play with his broken rib. He is listed as questionable on the injury report, along with guard Nick Cole, who is nursing a sore knee.
Max Jean-Gilles is expected to start again at right guard in place of Cole.
Practice squad wide receiver Chad Hall will make the trip to San Francisco, though he has not been officially signed yet. If he is, the Eagles will have to drop another player. Hall played some running back in the preseason, and could provide a receiving option out of the backfield if the team wants to rest McCoy.
Much of the focus this week has been on McCoy, but losing Samuel for the week could be a significant setback. Joselio Hanson will fill in, along with Dimitri Patterson. Rookie Trevard Lindley may also get a look in some situations, Reid said.
The defensive line will also have a different look in its base package, with Juqua Parker replacing Brandon Graham at defensive end. Reid said Graham will still get his share of snaps in other formations.
"(Parker) has been playing well, so he deserves a chance to be on that first group," Reid said.
The change is the second one on defense after the group got run on by the Redskins last week. Defensive coordinator Sean McDermott also promoted Moise Fokou ahead of Akeem Jordan at strong side linebacker.
Samuel has not passed his concussion tests after being hurt Sunday. Cooper initially passed one test, but was still showing some concussion symptoms, Reid said.