LeSean McCoy will start, as expected, that is all ye need to know. The Eagles running back with the toe bruise was deemed a game-time decision, but McCoy never had any intention of sitting. He may not be 100 percent, but I suspect Andy Reid won't ignore his best offensive weapon two weeks in a row. That is a good thing, in case you didn't know. So more McCoy means a balanced offense and one that should take advantage of Seattle's inconsistent defense.
On defense, the Eagles have a couple of defensive ends that have some extra motivation going against their former team (the Seahawks have former Eagles defensive end and Mr. Happy-Go-Lucky Chris Clemons). Jason Babin and Darryl Tapp have differing feelings toward their old team -- Babin hates the organization, Tapp doesn't -- but I think the line, as a whole, will get after Seahawks quarterback Tarvaris Jackson. The rest will take care of itself, even if Nnamdi Asomugha (knee) is limited. Eagles, 23-20.
What goes right: DeSean Jackson actually catches a ball over the middle.