Saturday, April 6, 2013
Saturday, April 6, 2013

HPV vaccine: Why should my teen get it?

Paul Offit, M.D., the director of the vaccine education center at the Children's Hospital of Philadelphia, tells us more about the HPV vaccine and how it can protect against cervical cancer in females and cancer in the head and neck cancer in males.

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HPV vaccine: Why should my teen get it?

POSTED: Wednesday, April 3, 2013, 9:21 AM

Despite the recommendation from experts, parents are increasing citing safety concerns as their reason to not vaccinate their teenage daughters against HPV, the virus that causes the most cases of cervical cancer, according to a recent study.

The study in the April issue of Pediatrics looked at vaccination rates among teens in the United States for several illnesses, including genital human papillomavirus. HPV, the most common sexually transmitted virus in the U.S., has been linked to cervical cancer, genital (anus, vagina, penis) cancers, and a type of head and neck cancer.

Researchers found a dramatic increase in the number of parents citing "Safety concerns/side effects" as their main reason for not vaccinating their daughters between 2008 and 2010. It jumped from 4.5 percent in 2008 to 16.4 percent in 2010.

The study did find a growing number of U.S. girls were vaccinated against HPV. The percentage of 13 to 17-year-olds who were not up-to-date on the vaccine fell from 84 percent to 75 percent. However, only 32 percent of girls from ages 13 to 17 were fully vaccinated against HPV in 2010. The three-shot vaccination hasn't been linked to any serious side effects.

The researchers also cited other reasons parents decided not to vaccinate:

“The consistent 11 to 14 percent of parents who gave the main answer “Not sexually active” illustrates that parents mistakenly perceive this vaccine is related to and necessary only if there is current sexual activity. Another consistent response, given by 14 to 17 percent of parents across the 3 years studied, was that the HPV is “Not needed or not necessary” despite the high prevalence rates of HPV infection and of the infections dire consequences suffered later in life.”

We asked Paul A. Offit, MD, the chief of the division of infectious diseases and the director of the vaccine education center at the Children’s Hospital of Philadelphia, to tell us more about the HPV vaccine and address safety concerns parents may have about it. He specializes in infectious diseases and is an expert on vaccines, immunology, and virology.

Who should get the HPV vaccine and when?

It’s recommended for adolescent boys and girls, 11 to 13 years of age.

What does it protect against?

There are about 100 types of papillomaviruses. Some types of papillomaviruses cause warts on the skin, some types cause warts in the anal and genital areas, and some types cause cervical cancer.

Many different HPV types cause cervical cancer. Two types (16 and 18) are the most common, accounting for about 70 percent of all cases of cervical cancer. Similarly, many types of HPV cause anal and genital warts; but only two types (6 and 11) account for about 90 percent of cases. One vaccine, Gardasil, contains types 6, 11, 16 and 18. I recommend this vaccine since it protects against four strains. Another HPV vaccine, Cervarix, contains types 16 and 18 only.

Cervarix and Gardasil protect against cervical cancers in women. Gardasil also protects against genital warts and cancers of the anus, vagina and vulva. Both vaccines are available for females. Only Gardasil is available for males.

What many parents don’t know is that it’s also cancer preventing in males. It protects against cancer in the head area such as the throat, nose, and neck.

How is the vaccine made?

The vaccine is made using a protein that resides on the surface of the virus. The protein is grown in the lab in yeast cells. It will make a virus protein when the yeast cell reproduces itself, then the protein forms something called a virus-like particle. It looks like the virus under a microscope, but most importantly, it doesn’t contain HPV genetic material so it can’t reproduce itself like actual virus and cause illness.

Should I have any safety concerns about the vaccine?

Gardasil was tested in 30,000 people for seven years before Food and Drug Administration approval. Studies determined that the vaccine was 91 percent effective at preventing infections, 100 percent effective at preventing persistent infections, and 100 percent effective at preventing Pap smear changes that predict cervical cancer.

It was tested in another 190,000 women after FDA approval. The only problem that comes up in boys and girls is fainting during the shot. Sometimes it happens when the needle is unsheathed before the shot.

There have been concerns raised from bad information on the internet. There has been no causal relationship shown between the vaccine and adverse events such as blood clots, chronic fatigue syndrome, strokes or seizures. It’s now been given to tens of millions of people without any problems.

What are some side effects? Are they common?

The vaccine may cause pain, redness and tenderness at the site of injection. The vaccine may also cause a slight fever. It is a small price to pay to avoid cancer. It prevents the only known cause of cervical cancer.

Is the vaccine necessary for my child? Is it only for sexually active teens?

It only works as a preventative, not as a treatment. It needs to be given before a teen becomes sexually active in order for it to work. It is assumed that virtually all people will become sexually active at some point. Both of my children, who were adolescents at the time, were vaccinated when it came out about seven years ago.

Some parents falsely believe that vaccination will likely lead to their teen becoming promiscuous. A recent study that followed 11 to 12- year-old girls for three years found no difference between vaccinated and non vacinated girls with having taken a pregnancy test, been tested for sexually transmitted diseases, or been counseled for the use of contraceptives.

Every year, over 26,000 people in the U.S. are diagnosed with head, neck, or cervical cancers. The vaccine may have prevented these cases.


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Comments  (5)
  • 0 like this / 0 don't   •   Posted 1:41 PM, 04/03/2013
    Every jawn should get it because I want to make sure I don't catch anything from any of my jawns.
    Lil Tyreese Biggums
  • 0 like this / 0 don't   •   Posted 3:16 PM, 04/03/2013
    I wonder how many of these concerned parents think that this will cause retro-autism? Thanks, Jenny McCarthy.
    verve
  • 0 like this / 0 don't   •   Posted 4:56 PM, 04/03/2013
    Mostly minority women get cervical cancer after having many partners. Vaccine should be targeted towards minority women.
    Pugh
  • 0 like this / 0 don't   •   Posted 7:56 PM, 04/03/2013
    It is ridiculous that there is any controversy with this. The anti-vax nutcases aside, HPV vaccine is controversial because Americans talk about sex with all the maturity of a giggling twelve-year-old, or don't talk about it at all.
    People need to get over the fact that teenagers have sex and there isn't anything we can, or should do to stop it. Sex is a normal, healthy activity as well as an essential biological function. We shouldn't be focusing on ways to prevent teens from having sex, we should focus on making it as safe as possible and on preventing as many unintended pregnancies as we can.
    We need to stop allowing the church to dictate policy, and parents need to grow up and realize that preventing your children from being vaccinated against HPV can have serious, even fatal consequences for those children later in life.
    jerkoftheworld
  • 0 like this / 0 don't   •   Posted 7:04 PM, 04/04/2013
    Paul Offit is very well aware that the Vaccination Compensation Program has paid almost 6 million dollars to compensate 49 victims of Gardasil (including 2 deaths). There are almost 100 other cases pending. Paul Offit makes money off vaccines. He loves vaccines. He will tell you anything you want to hear so that you will get every vaccine that comes out on the market. Paul Offit says that a baby can get 10,000 vaccines safely. Tell that to parents of a vaccine inured child. There are over 29,000 people who have reported an adverse event from Gardasil to the Vaccine Adverse Event Reporting System. Do you believe that all of them are unconnected? Or only the minor side effects are connected? 130 deaths have been reported to VAERS, over 5,000 people have not recovered, and 10,000 people had to go to the ER. All not connected? Everyone wants to end cervical cancer; everyone wants to protect their child against throat cancer. Are there other ways to protect yourself if you do not vaccinate with Gardasil? Definitely! Don’t smoke, don’t have sex with multiple partners, eat a diet rich in vitamins including lots of fruit and vegetables, supplement with vitamin C and get your pap smears which have significantly lowered the rate of cervical cancer. By the way, 60 reports have been made to VAERS of Cervical Cancer after Gardasil. Turns out if you have already been exposed to one of these strains of HPV and you receive Gardasil it can raise the risk you will develop cervical cancer by 44%. Ask to read the Gardasil insert where you will see a plethora of information about the risks of this vaccine. None of the promoters of Gardasil will be by your side when your child’s immune system is triggered to attack its own body. DO YOUR RESEARCH.
    offitlies


About this blog
The Healthy Kids blog is your window into the latest news, research and advice around children's health. Learn more about our growing list of contributors here. Reach Healthy Kids at HealthyKids@philly.com.

Anna Nguyen Healthy Kids blog Editor
Stephen Aronoff, M.D., M.B.A. Temple University Hospital
Christopher C. Chang, M.D., Ph.D Nemours/Alfred I. duPont Hospital for Children, Jefferson Medical Colg
Katherine K. Dahlsgaard, Ph.D. Lead Psychologist - The Anxiety Behaviors Clinic, CHOP
Gary A. Emmett, M.D. Pediatrics Professor- Thomas Jefferson Univ. & Director, Hospital Pediatrics- TJU Hospital
Lauren Falini Bariatric exercise physiologist, Nemours/Alfred I. duPont Hospital for Children
Hazel Guinto-Ocampo, M.D. Nemours duPont Pediatrics/Bryn Mawr Hospital
Rima Himelstein, M.D. Crozer-Keystone Health System
W. Douglas Tynan, Ph.D. Nemours/Alfred I. duPont Hospital for Children, Jefferson Medical Colg
Beth Wallace Registered dietitian, Children's Hospital of Philadelphia
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