Thursday, April 2, 2015

FDA can help reduce dabigatran (PRADAXA) bleeding

Monday, February 17, 2014, 9:23 AM
Two recently published studies of one of the newer blood thinners, Pradaxa, point the way to reducing the risk of its major drawback—high rates of bleeding of 16% a year. Pradaxa was approved in October 2010 as an alternative to the standby blood thinner Coumadin (warfarin). Both are effective... Read more

Oral rotavirus vaccine is ineffective by injection

Tuesday, February 11, 2014, 12:05 PM
Rotavirus is a virus that causes a type of gastroenteritis (inflammation of the lining of the stomach and intestines) that can lead to severe watery diarrhea, vomiting, fever, and abdominal pain. According to the CDC, rotavirus gastroenteritis can also lead to dehydration (loss of body fluids) in babies... Read more

Drug prices: Higher and higher

Thursday, January 30, 2014, 11:59 AM
In an effort save money on continually rising drug costs, the Germans passed the Reform of the Market for Medicinal Products act in 2010 to assess whether newly approved brands in that country justify their higher prices with greater benefits than older products. Germany's Federal Joint Committee... Read more

Critical IV solution shortage affecting US hospitals

Monday, January 27, 2014, 9:31 AM
The country is experiencing a serious shortage of certain IV fluids, mainly involving sodium chloride injection 0.9% (IV saline) in 1,000 mL bags. Some hospitals have also been short of Lactated Ringer’s solution. Smaller size bags are available right now but we’re hearing that those... Read more

Pharma's 2014 outlook and Merck's changing culture

Monday, January 20, 2014, 10:35 AM
Citigroup recently issued its 2014 outlook for European and US pharmaceutical companies. While their outlook is generally bullish, the positive signs they emphasize for the industry are more notable for what they omit than for what they tout. For example, some of their up-indicators include a more... Read more

Challenges for Merck's Venture in Weight Loss Management

Thursday, January 9, 2014, 6:00 AM
In the week before Christmas, Merck announced (see here) that it was starting a weight loss business as a self-supporting enterprise. In the past, whenever pharmas launched businesses outside of prescription and non-prescription pharmaceuticals, they were typically "value-added" enterprises designed... Read more

Contact lens wearers — beware when using Clear Care

Tuesday, January 7, 2014, 10:42 AM
In December 2010 and again in May 2012, Check-Up warned consumers who wear contact lenses about Clear Care, a lens cleaning product from Ciba Vision (a Novartis company) that contains hydrogen peroxide. The product must only be used to soak contact lenses within a special lens case that deactivates... Read more

A lesson from not prosecuting the banks

Tuesday, December 31, 2013, 6:00 AM
Anyone who's been awake the past five years knows that the U.S. experienced its worst economic recession since the 1930s as a result of fraudulent manipulations by investment banks and other financial institutions. Equally galling has been the lack of criminal action against these Wall Street fraudsters... Read more

Adverse effects of numbing medications for teething in babies

Monday, December 30, 2013, 6:00 AM
What do you do when your baby who is teething starts kvetching and crying? Let me tell you what not to do. Many parents like to rub numbing medications on their baby’s gums to treat the discomfort. Products for this purpose, called topical anesthetics, are available for purchase over the counter... Read more

A step in the right direction for Pharma

Thursday, December 26, 2013, 9:45 AM
Given pharma's way of doing business during the past decade, it’s become extremely difficult to identify emerging patterns that deserve an attaboy. That’s all the more reason to commend GlaxoSmithKline’s management for two steps they took last week. The company’s CEO, Andrew... Read more
About this blog

Check Up covers regional health news and a wide array of healthcare topics from pharmaceutical happenings to patient safety. Read about some of our bloggers here.

Portions of this blog may also be found in the Inquirer's Sunday Health Section.

Michael R. Cohen, R.Ph. President, Institute for Safe Medication Practices
Daniel R. Hoffman, Ph.D. President, Pharmaceutical Business Research Associates
Hooman Noorchashm, M.D., Ph.D. Cardiothoracic surgeon in the Philadelphia area
Amy J. Reed, M.D., Ph.D. Anesthesiologist and Surgical Intensivist in the Philadelphia Area
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