Guyism, the invaluable website that is a human genome project for those who possess the XY chromosome, explains the distinctive features of the male grossout comedy.
For those who don't want to click through, Max Steven Miller inventories the essentials. They include: Wishful-thinking hookups (Adam Sandler gets to have sexual relations with Salma Hayek and Brooklyn Decker in his movies); Resurrecting the career of a forgotten icon (Mike Tyson in The Hangover, Neil Patrick Harris in Harold & Kumar Go to White Castle); Getting wasted (every male buddy movie from Animal House forward).
Some female-buddy comedies such as The Sweetest Thing (raunchy fun with Camera Diaz and Christina Applegate) rely on the same tropes as the male-grossout movies. But if I were to deliver the 10 Commandments of the female-buddy comedy, the list would include such gender-specific imperatives as:
Thou shalt make a shoe joke. (In Clueless, Alicia Silverstone defends her virginity with the line, "You know how picky I am about my shoes and they only go on my feet.")