The Colts have ruled out running back Joseph Addai (neck) and four other players for Sunday's game against the Eagles.
Addai did not travel with the team to Philadelphia. Tight end Brody Eldridge (rib), running back Mike Hart (ankle), linebacker Clint Session (elbow) and defensive back Justin Tryon (foot) all did not make the trip.
With both Addai and Hart sidelined, Donald Brown will make his first career start, despite the fact that he is still hampered by a hamstring injury. Brown had 16 yards on nine carries Monday night against the Texans in his first action since Week 3.
The Colts are second in the NFL in total offense, and not because of their run game, which ranks 23rd. Peyton Manning has been sacked only seven times this season and has been a master at dealing with the blitz.
Indianaolis also put wide receiver Anthony Gonzalez on injured reserve with a torn ligament in his knee.
The Colts already had ruled out defensive tackle Antonio Johnson (knee) and safety Bob Sanders (biceps) were ruled out Friday.