The Manning Family QBs (Archie, Peyton and Eli) have won seven of their last 10 meetings with New England, which comes after a 2-13 start against the Patriots (*postseason game):
| Date | Manning | Team | Site | Result |
| Dec. 10, 1972 | Archie | Saints | New Orleans | L 10-17 |
| Dec. 21, 1980 | Archie | Saints | New Orleans | L 27-38 |
| Nov. 28, 1982 | Archie | Oilers | New England | L 21-29 |
| Sept. 13, 1998 | Peyton | Colts | New England | L 6-29 |
| Nov. 1, 1998 | Peyton | Colts | Indianapolis | L 16-21 |
| Sept. 19, 1999 | Peyton | Colts | New England | L 28-31 |
| Dec. 12, 1999 | Peyton | Colts | Indianapolis | W 20-15 |
| Oct. 8, 2000 | Peyton | Colts | New England | L 16-24 |
| Oct. 22, 2000 | Peyton | Colts | Indianapolis | W 30-23 |
| Sept. 30, 2001 | Peyton | Colts | New England | L 13-44 |
| Oct. 21, 2001 | Peyton | Colts | Indianapolis | L 17-38 |
| Nov. 30, 2003 | Peyton | Colts | Indianapolis | L 34-38 |
| *Jan. 18, 2004 | Peyton | Colts | New England | L 14-24 |
| Sept. 9, 2004 | Peyton | Colts | New England | L 24-27 |
| *Jan. 16,2005 | Peyton | Colts | New England | L 3-20 |
| Nov. 7, 2005 | Peyton | Colts | New England | W 40-21 |
| Nov. 5, 2006 | Peyton | Colts | New England | W 27-20 |
| *Jan. 21, 2007 | Peyton | Colts | Indianapolis | W 38-34 |
| Nov. 4, 2007 | Peyton | Colts | Indianapolis | L 20-24 |
| Dec. 29, 2007 | Eli | Giants | Meadowlands | L 35-38 |
| *Feb. 3, 2008 | Eli | Giants | Glendale | W 17-14 |
| Nov. 2, 2008 | Peyton | Colts | Indianapolis | W 18-15 |
| Nov. 15, 2009 | Peyton | Colts | Indianapolis | W 35-34 |
| Nov. 21, 2010 | Peyton | Colts | New England | L 28-31 |
| Nov. 6, 2011 | Eli | Giants | New England | W 24-20 |
| Feb. 5, 2012 | Eli | Giants | Indianapolis | — |