Oprah Winfrey (4 p.m., 6ABC) - Oprah and comic Chris Rock discuss topics from the past week; Michael Buble performs.

Smallville (8 p.m., CW57) - Zod (Callum Blue) and his troops release an airborne virus that turns humans into zombies, and only an antidote made from the blood of another Kryptonian can stop it.

Medium (9 p.m., CBS3) - Allison (Patricia Arquette) fears the worst when a friend of hers who has cancer dies unexpectedly. She suspects the woman fell victim to foul play, not her illness.

Hitch (9 p.m., TNT) - Will Smith's charisma is set on high in this enjoyable 2005 comedy that casts him in the title role as an expert on romance who charges a fee for sharing his wisdom with those who have problems with their social lives. The main client (Kevin James) has an eye on a supermodel type, appropriately portrayed by Amber Valletta, but Hitch has his own love problem, furnished by a reporter (Eva Mendes) who sets him off his game.

The Jay Leno Show (10 p.m., NBC10) - Former NFL player Terry Bradshaw.

Late Show With David Letterman (11:35 p.m., CBS3) - Actor Jon Hamm; comic Andy Kindler; Brett Dennen performs.

Jimmy Kimmel Live (12:06 a.m., 6ABC) - Director Michael Moore; actress Malin Akerman; Backstreet Boys perform.

The Late Late Show With Craig Ferguson (12:37 a.m., CBS3) - Actor Gerard Butler; Phoenix performs.

Late Night With Jimmy Fallon (12:37 a.m., NBC10) - Actor Martin Short; real estate investor Jeff Lewis; Cory Chisel performs.